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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS2
All Species:
6.97
Human Site:
Y392
Identified Species:
15.33
UniProt:
Q07890
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07890
NP_008870.2
1332
152979
Y392
M
D
R
I
Y
K
Q
Y
S
P
R
R
R
P
G
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
S659
M
E
K
I
C
S
K
S
L
A
K
R
R
L
S
Rhesus Macaque
Macaca mulatta
XP_001099864
1331
152695
H392
M
D
R
I
Y
K
Q
H
S
P
R
R
R
P
G
Dog
Lupus familis
XP_547804
1363
156214
Y423
M
D
R
I
Y
K
Q
Y
S
P
R
R
R
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q02384
1333
153108
H393
M
D
R
I
Y
K
Q
H
S
P
R
R
R
P
G
Rat
Rattus norvegicus
NP_001129033
1333
153157
H393
M
D
R
I
Y
K
Q
H
S
P
R
R
R
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515100
1332
152934
H392
M
E
R
I
Y
R
Q
H
S
P
R
R
R
P
G
Chicken
Gallus gallus
XP_421461
1466
167231
H528
M
E
R
I
Y
S
K
H
S
P
R
R
R
P
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_690171
1343
153249
H389
I
E
R
I
Y
A
K
H
Q
P
R
R
K
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
L438
L
E
K
V
M
A
S
L
S
K
E
R
Q
V
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
H392
L
D
R
I
C
A
G
H
L
P
K
R
K
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
99
93.2
N.A.
94.9
94.6
N.A.
91.1
78.9
N.A.
73
N.A.
39.8
N.A.
N.A.
52.1
Protein Similarity:
100
68.5
99.7
95.5
N.A.
97.9
97.4
N.A.
95.9
84.7
N.A.
83.9
N.A.
55.1
N.A.
N.A.
68
P-Site Identity:
100
26.6
93.3
100
N.A.
93.3
93.3
N.A.
80
73.3
N.A.
46.6
N.A.
13.3
N.A.
N.A.
40
P-Site Similarity:
100
53.3
100
100
N.A.
100
100
N.A.
100
93.3
N.A.
80
N.A.
46.6
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
28
0
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
19
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
55
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
46
0
0
0
0
0
0
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
82
% G
% His:
0
0
0
0
0
0
0
64
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
91
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
19
0
0
46
28
0
0
10
19
0
19
0
0
% K
% Leu:
19
0
0
0
0
0
0
10
19
0
0
0
0
10
0
% L
% Met:
73
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
82
0
0
0
64
10
% P
% Gln:
0
0
0
0
0
0
55
0
10
0
0
0
10
10
0
% Q
% Arg:
0
0
82
0
0
10
0
0
0
0
73
100
73
0
0
% R
% Ser:
0
0
0
0
0
19
10
10
73
0
0
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% T
% Val:
0
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
73
0
0
19
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _